What is CBD? Can It be Abused, Create Dependence, and Treated? FHE Health

Some studies also mention its potential as a supportive agent in overcoming the withdrawal symptoms after cessation. All these interactions seem promising when it comes to easing withdrawal symptoms and reducing the risk of addiction. Still, there’s one more thing we’d like to cover before we move on to the benefits of CBD for addicted individuals.

Therein, CBD attenuated jumping, defecation and rearing behavior in the mice (Bhargava, 1976). In another study, the effects of CBD (5, 20, or 80 mg/kg) were tested on mice given morphine before naloxone for precipitated quasi-morphine withdrawal syndrome. However, none of the CBD doses successfully in ameliorating the behavioral signs of withdrawal (Chesher and Jackson, 1985) (Table 1). The present systematic review has its own limitations, including the lack of a mechanism to exclude publication bias and the fact that no search for unpublished studies was achieved. A limited number of studies on the direct impact of CBD on addictive behaviors are available in the literature, and the majority use animal models of addiction.

Is Cannabidiol (CBD) Addictive?

Numerous studies were carried out to elucidate the interactive mechanisms between CBD and ECS components. One of the mechanisms is the inhibition of AEA hydrolysis and reuptake by blocking its catabolic enzyme (FAAH) and the corresponding membrane transporter, respectively (Bisogno et al., 2001; Laprairie et al., 2015). Regarding the interaction with CB1R, CBD was first thought to be an antagonist (Thomas et al., 2007; Pertwee, 2008), but recent results suggested that CBD could act also as a non-competitive negative allosteric modulator of CB1R (Laprairie et al., 2015; Tham et al., 2019). https://ecosoberhouse.com/article/sober-life/ Interestingly, a statistical meta-analysis of all present information describing direct effects of CBD at cannabinoid receptors concluded that there is no direct CBD–CB1R interaction that may account for the reported changes in endocannabinoid signaling (McPartland et al., 2015). In summary, available evidence suggests that CBD-induced modulation of drug reinforcing and motivational properties could be mediated, at least in part, by the functional regulation of the opioidergic system. According to the previous evidence, it seems that CBD could play a crucial role in the management of CUD.

• Moreover, CBD’s influence on the rewarding characteristic of morphine in the CPP paradigm has also been evaluated.
• Nevertheless, more studies are needed to precisely explore CBD-mediated regulation of dopaminergic mechanisms involved in drug addiction.
• Doctors prescribe opioid drugs such as morphine and oxycodone to manage severe neuropathic pain or injury.

Addiction specialists have discovered that genetics and environmental factors influence one’s susceptibility to drug and alcohol abuse [2]. Hemp-derived CBD is known to be safe and well-tolerated in most people, even at high doses (50–100 MG). According to the World Health Organization, the research on CBD use in clinical trials is still quite limited, but CBD is shown to be well-tolerated and generally safe.

How long does a CBD high last?

Specifically, this chronic cannabinoid exposure altered PFC structure and impaired cortical synaptic plasticity from reduced long-term potentiation (LTP) in the hippocampus-PFC circuit. These findings support the theory that adolescent cannabis use causes lasting deficits in memory. However, they are likely age-specific effects as preclinical and clinical studies have demonstrated a lack of long-lasting cognitive impairments from adult chronic cannabis use (Renard et al. 2016). In the context of reinstatement, cocaine-induced reconsolidation and priming-induced reinstatement remained unchanged following CBD (10 mg/kg) treatment (Chesworth and Karl, 2020; Luján et al., 2018).

They tested this by giving various dosages of CBD to people who frequently smoke marijuana compared to a placebo. When talking about addictive substances, the substances are often tested to see how they affect a person on a molecular level. Elsewhere, CBD (20 mg/kg) failed to impact extinction training but reduced ‘extinction burst’ behavior, defined as the paradoxical enhancement of operant responding in mice (Luján et al., 2021) (Table 1). BA in EnglishKatrina has always had a passion for health sciences and literature. She works as a content writer, editor, and strategist in the health and wellness space, primarily focusing on cannabis education.

CBD as a Potential Treatment for Addiction

Also, CBD (10 mg/kg, i.p.) disrupted the reconsolidation of place preference in rats and this effect was present for 2 weeks (de Carvalho and Takahashi, 2017). Very recently, Chesworth and Karl exhaustively explored CBD actions (10 mg/kg, i.p.) is cannabidiol addictive on the acquisition, consolidation, reconsolidation, extinction, and drug-primed reinstatement of cocaine (15 mg/kg) in the CPP paradigm. CBD significantly reduced the preference for the cocaine-context and the consolidation of cocaine memory.

In recent years, the major role of hippocampal neurogenesis in the addictive process has become increasingly established (Mandyam and Koob, 2012; Chambers, 2013; Deroche-Gamonet et al., 2019). A number of reports suggests that psychoactive substances with addictive potential modify neurogenesis in the adult HIPP (Castilla-Ortega et al., 2016). The subventricular zone (SVZ) and the subgranular layer of the hippocampal dentate gyrus (DG) are the brain regions where adult neurogenesis occurs.